![]() ![]() A novel 15-gene signature was constructed and could predict the prognosis of PAAD. The TIDE algorithm predicted that the low-risk group was more responsive to immune checkpoint blockade therapy than the high-risk group. The TCGA PAAD cohort could be divided into two distinct risk groups based on the expression of GSDMC-related genes (GRGs). ![]() GSDMC expression and the relationship between GSDMC and patient survival or immune infiltration in PAAD were examined using data in the The Cancer Genome Atlas (TCGA), Gene Expression Ominbus (GEO), Genotype-Tissue Expression (GTEx) and Cancer Cell Line Encyclopedia (CCLE) databases. However, whether GSDMC expression in PAAD is associated with survival or response to immunotherapy remains unknown. Gasdermin C (GSDMC) induces pyroptosis in cancer cells and inflammation in the tumor microenvironment. Pancreatic adenocarcinoma (PAAD) has a poor prognosis and is relatively unresponsive to immunotherapy. ![]()
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![]() Sects and the Single Girl involves a smarmy preacher - of the Church of Stary Wisdom - and a conniving minx with plans of her own. I didn't expect much from it, perhaps because of the Cthulhu element, but the stories are generally well-written, with beginning, middle and end, and usually with tongue firmly planted in cheek, albeit, since this is an homage to Lovecraft's grim and hopeless world, there are more than a few stories that end with the sacrifice of the focal character. It contains sixteen short stories that mash-up urban fantasy and the Cthulhu mythos. This is a surprisingly entertaining story collection. Please give me a helpful vote on Amazon. ![]() The First United Church of Cthulhu is the only real and legally recognized nonprofit religious organization whose faith is based on the Cthulhu Mythos and the visions of our mad prophet H. Virgin Mother of a Thousand Young” by Kevin Wetmore “Saturday Night at the Esoteric Order of Dagon” by Jill Hand “Uncle The Complete Oral History” by David Acord “Along the Shore of Old Ridge” by Stuart Conover “Cosmic Cavity or, the Mouth of Man” by Carl R. “The Black Metal of Derek Zann” by Aaron Besson “The Kings in Rebel Yellow” by Khurt Khave ![]() And they want in!įeatures the work of prominent horror authors, many already with published Cthulhu Mythos material. In the dark recesses of the world's cities lie the hidden altars and secret cathedrals dedicated to the blasphemous beings from out of space and time. Published by the First United Church of Cthulhu ![]() URBAN TEMPLES OF CTHULHU – MODERN MYTHOS ANTHOLOGY ![]() ![]() ![]() 2 of Baroque Works, but the Straw Hats see it as good fortune to have met him and wear white bandages on their lower arms so they will know if Bon Kurei is imitating one of them. Just as they leave, Vivi realizes that he is Mr. Bon Kurei is then picked up by his own ship and crew and leaves, swearing on friendship. He imitates everybody on the ship except Sanji, who was cooking at the moment, and Vivi, who he simply did not touch. The crew pulls him up and quickly befriend him, mainly due to how entertaining he is, especially with his ability to transform into other people with the Mane Mane no Mi. 2, who coincidentally took a similar course, on their fishing rods. Suddenly, they steer through a hot spot (an undersea volcano making the sea above steaming hot), Usopp and Luffy catch Mr. Vivi explains that Crocodile is seen as a hero in Arabasta and that no one suspects that he plans to take over the kingdom. ![]() The Going Merry is on its way to Arabasta and the crew is trying to catch fish to eat. 1.5 Arriving in Alubarna: The War Begins!. ![]() ![]() ![]() ![]() The violence isn't described in detail but there are bombings, lynchings, rapes, girls being carried off buses and people arrested. ![]() The main character becomes pregnant, unmarried, and there is some innuendo used to abuse. Readers will never forget this book and will, years from now, be urging their teenager to read and learn about Claudette Colvin, "the girl who got arrested".Īs you can see, I gave full marks for educational material, positive messages, and good role models however, I did have a pause when it came to the sexual content. I loved the steady pace, detailed reality, and hope displayed on the pages that told of the greatest spark of the civil rights movement. ![]() I couldn't wait every time I picked up the book to start reading and learn about this forgotten, yet influential, historical figure's story. Philip Hoose did the best research I have probably ever seen for a biography. Realistic, hopeful, educational, and superbly researched, this is a teacher's powder puff dream for their middle grade students. Most people moan and groan when they are forced to read a biography and think about the thousands of times they'll be caught looking out the window, but this one will keep even the reluctant reader glued. This book immediately went on my very short list of admirable and can't-stop-reading Newberry books from the moment I read the first chapter. ![]() ![]() ![]() Unvarnished pages and an elegant layout enhance the sense of magic in a natural world just out of view. The rhythm of the girl’s discoveries balances thoughtful discovery with moments of muted excitement, as when she skis downhill, then watches a fox pounce on a mouse (“His paws scratch away to find the mouse he heard scritch-scritch-scratching along underneath”). Kate Messner is a middle school teacher and the author of several books for young readers, including the Sea Monster series. ![]() A human father and daughter are tiny figures in a field of white, cross-country skiing past fir trees and glimpsing the occasional animal, while other creatures are visible in cutaway views below ground (“Under the snow, a queen bumblebee drowses away December, all alone. I lick sticky marshmallow from my lips and lean back with heavy eyes”) with debut illustrator Neal’s quiet, woodcut-like portraits of the snowy forest. Straddling the informative and the evocative, this lovely study of the ways animals spend the winter in a “secret kingdom under the snow” combines Messner’s (Sea Monster’s First Day) graceful prose (“Over the snow, the fire crackles, and sparks shoot up to the stars. ![]() ![]()
![]() ![]() And thus a virtual long-distance relationship ensues, which is really a ménage-à-trois.Īfter «The Three Musketeers», who continue to gallop across the Residenztheater stage, the Italian director Antonio Latella and his co-writer and dramaturg Federico Bellini now tackle the second great classic about famous swordsmen. Instead he becomes the ghost writer for his regimental colleague Christian de Neuvillette, whom Roxane loves for his beautiful exterior, but who is unable to write beautiful letters. However, what is probably the second most famous nose in world literature after Pinnochio’s seems to be an invention of the author, as is the fatal love triangle that dominates the play’s narrative: Cyrano loves Roxane but does not dare declare his passion because he is so ugly. However, rather than his own works he owes his fame more to the 1897 play by the new romantic dramatist Edmond Rostand whose hero bears his name and, like his historical predecessor, is a poet who serves as a musketeer with the Gascony cadets. The historical Cyrano de Bergerac lived the life of a dandy, duellist and poet, a philosopher of the early Enlightenment and a science fiction writer in 17 th century France. ![]() ![]() ![]() ![]() Then two university ensembles, Trinity Orchestra and UCD Symphony Orchestra, said they would remove all music by Russian composers from the repertoire The orchestra of the Ukrainian National Tchaikovsky Academy of Music performing in central Kyiv in March (Photo: Yevhen Kotenko/ Ukrinform/Future Publishing via Getty Images) Switzerland’s Théâtre Bienne Soleure replaced Tchaikovsky’s Ukraine-based romantic opera Mazeppa over concerns about depicting war on stage, while the Polish National Opera cancelled a performance of Modest Mussorgsky’s opera Boris Godunov, about the downfall of a murderous tsar. This month, the Cardiff Philharmonic Orchestra cancelled a Tchaikovsky evening because of the conflict, while the Russian composer’s 1812 Overture was dropped from the Royal Albert Hall’s Classical Spectacular concerts, by Japan’s Chubu Philharmonic, by the Akashi Philharmonic and the Zagreb Philharmonic. ![]() ![]() ![]() ![]() 'Essential reading for all women over 40, and their doctors!' Dr Natasha Andreadis, fertility specialist and host of the Fanny Mechanic podcast Prior MD, author of Estrogen's Storm Season 'This lively, clear and supportive book provides positive and helpful information that many women need as they approach perimenopause and beyond.' Jerilynn C. The Hormone Repair Manual is backed by evidence-based research and case studies and is a reassuring guide to soothing, nourishing and strengthening your body, mind and spirit during this time of change. a focus on health during this period can bring benefits for years to come.Īddressing common symptoms such as hot flushes, insomnia, mood changes, migraines, weight gain, low libido and heavy periods, Lara offers practical solutions of diet, lifestyle, nutritional supplements and tips for how to speak to your doctor about hormone therapy. emotional challenges can present an opportunity to thrive many symptoms are temporary and manageable Her fresh approach aims to overturn the stigma of perimenopause and menopause and show women that: ![]() ![]() Naturopath Lara Briden, author of the international bestseller Period Repair Manual, has more than 20 years' experience in women's health. The Hormone Repair Manual is a must-have guide to understanding and overcoming the symptoms of perimenopause and menopause. 'The book my patients have been waiting for.' Dr Peta Wright, gynaecologist and women's health advocate ![]() ![]() Of his courage I can give no praise that is high enough. He was the life and soul of the mess-always so willing and cheery. I feel it most terribly myself, and so do all the other officers and men of the battery. writes:-”I cannot express my deep sympathy for you in your great bereavement. ![]() He saw much active service round Ypres during last October. As the result of a serious accident in camp he was gazetted out of the Army in 1916 but he never rested until he had passed the medical board as fit, and obtained another commission in March, 1917, in the R.F.A. He returned to England, joined the University of London O.T.C., and got his commission in the R.F.A. ![]() At the outbreak of the war Lieutenant Hodgson as living at Sanary, on the South Coast of France. He was awarded the Royal Humane Society’s medal for saving life at sea. He was a notable athlete, a fine boxer, a strong swimmer, and an all-round good sportsman. His early days were spent in the merchant service, where he gathered his material for many of his thrilling sea stories. Samuel Hodgson, and the author of “The Boats of the Glen Carrig,” “The Night Land,” “Men of the Deep Waters,” and other books. ![]() HOPE HODGSON, R.F.A., killed in action on April 17, was the second son of the late Rev. ![]() |